Drug Table
Drug Initial Daily Dose(s) Maximum Daily Doses(s)
ACE Inhibitors
Captopril 6.25 mg tid 50 mg tid
Enalapril 2.5 mg bid 10–20 mg bid
Fosinopril 5–10 mg qd 40 mg qd
Lisinopril 2.5–5 mg qd 20–40 mg qd
Perindopril 2 mg qd 8–16 mg qd
Quinapril 5 mg bid 20 mg bid
Ramipril 1.25–2.5 mg qd 10 mg qd
Trandolapril 1 mg qd 4 mg qd
ARBs
Candesartan 4–8 mg qd 32 mg qd
Losartan 25–50 mg qd 50–150 mg qd
Valsartan 20–40 mg bid 160 mg bid
ARNI
Sacubitril/valsartan 49/51 mg bid (therapy may
be initiated at 24/26 mg bid)
97/103 mg bid
I
f
channel inhibitor
Ivabradine 5 mg bid 7.5 mg bid
Aldosterone Antagonists
Spironolactone 12.5–25 mg qd 25 mg qd or bid
Eplerenone 25 mg qd 50 mg qd
Beta Blockers
Bisoprolol 1.25 mg qd 10 mg qd
Carvedilol 3.125 mg bid 50 mg bid
Carvedilol CR 10 mg qd 80 mg qd
Metoprolol succinate
extended release
(metoprolol CR/XL)
12.5–25 mg qd 200 mg qd
Isosorbide dinitrate and hydralazine
Fixed-dose combination 20 mg isosorbide
dinitrate/37.5 mg
hydralazine tid
40 mg isosorbide dinitrate/
75 mg hydralazine tid
Isosorbide dinitrate and
hydralazine
20–30 mg isosorbide
dinitrate/25–50 mg
hydralazine tid or qid
40 mg isosorbide
dinitrate tid with
100 mg hydralazine tid
Modified (Table 15) from the 2013 HF guideline
