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Estrogen and Progesterone Receptor Testing in Breast Cancer

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9 ≤10% of cells staining OR intensity is weak Step 2: Evaluate percent of cancer cells staining and stain intensity >10% of cells staining AND intensity is moderate or strong Take steps to confirm/ adjudicate result per labspecific SOP a and correlate with histology (See Table 1) Report as: ER Positive If result considered concordant with histology (See Table 1) <1% of cells staining 1-100% of cells staining Report as: ER Negative (reported data elements should include status of controls c ) ER Positive 1-10% of cells staining >10% of cells staining (but weak) Report as: ER Low Positive Add recommended comment b (reported data elements should include percentage of cells staining, intensity, and status of controls c ) Report as: ER Positive (reported data elements should include percentage of cells staining and intensity)

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