7
Table 2. Additional Recommended Reporting Comments for
Specific Scenarios
Result: Additional recommended comment:
1-10% cells staining: e cancer in this sample has a low level (1-10%) of ER
expression by IHC. ere are limited data on the overall
benefit of endocrine therapies for patients with low level
(1-10%) ER expression, but they currently suggest possible
benefit, so patients are considered eligible for endocrine
treatment. ere are data that suggest invasive cancers with
these results are heterogeneous in both behavior and biolog y
and oen have gene expression profiles more similar to ER
negative cancers.
No internal controls
and ER is 0-10%:
No internal controls are present, but external controls are
appropriately positive. If needed, testing another specimen
that contains internal controls may be warranted for
confirmation of ER status.
