Abbreviations
ACC, adrenocortical carcinoma; ACTH, adrenocorticotropic hormone; ADX, adrenalectomy;
BMAH, bilateral macronodular adrenal hyperplasia; BMD, bone mineral density; CBG,
corticosteroid binding globulin; CD, Cushing's disease; CNS, central nervous system; CS,
Cushing's syndrome; DDI, drug-drug interactions; EAS, ectopic ACTH secretion; ES,
Endocrine Society; f T4, free thyroxine; GC, glucocorticoid; GH, growth hormone; GI,
gastrointestinal; h, hours; HPA, hypothalamic-pituitary-adrenal; HRQOL, health-related
quality of life; HT, hypertension; HU, Hounsfield units; ICU, intensive care unit; IPSS,
inferior petrosal sinus sampling ; LFTs, liver function tests; QOL, quality of life; QTc, corrected
QT interval; RT, radiation therapy; SST, somatostatin receptor; T4, thyroid hormone; TSS,
transsphenoidal selective adenomectomy; UFC, urine free cortisol; WBC, white blood cell count
Source
Nieman LK, Biller BMK, Findling JW, et al. Treatment of Cushing's Syndrome: An Endocrine
Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-31.
Grading System
Strength of
Recommendation
1 = strong 2 = less strong
US = Ungraded best practice statement
Quality of
Evidence
⊕⊕⊕⊕
= high
⊕⊕⊕
= moderate
⊕⊕
= low
⊕
= very low
106 Commerce Street, Suite 105
Lake Mary, FL 32746
TEL: 407.878.7606 • FAX: 407.878.7611
Order additional copies at GuidelineCentral.com
Copyright © 2015 All rights reserved
ESCUS15123
Disclaimer
is Guideline attempts to define principles of practice that should produce high-quality patient care.
It focuses on the needs of primary care practice, but also is applicable to providers at all levels. is
Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining
the same results. e ultimate judgment concerning the propriety of any course of conduct must be
made by the clinician aer consideration of each individual patient situation.
Neither IGC, the medical associations, nor the authors endorse any product or service associated with
the distributor of this clinical reference tool.
