Endocrine Society GUIDELINES Bundle (free trial)

Cushing's Syndrome Diagnosis

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2018 All rights reserved ESCUSDx18103 Disclaimer is pocket guide attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels. is pocket guide should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. Source Nieman LK, Biller BMK, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. e Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. May 2008, 93(5):1526–1540. Abbreviations ACTH, adrenocorticotropic hormone; CBG, cortisol-binding globulin; CS, Cushing's syndrome; Dex-CRH; dexamethasone-suppressed corticotropin-releasing hormone; DST, dexamethasone suppression test; HPA, hypothalamic-pituitary-adrenal; HPLC, high- performance liquid chromatography; 11β-HSD2; 11β-hydroxysteroid dehydrogenase type 2; LC-MS/MS, tandem mass spectrometry; LDDST, low-dose DST; 17OHCS, 17-hydroxycorticosteroid; SMR, standard mortality ratio; UFC, urine free cortisol Grading System Strength of Recommendation 1 = strong 2 = conditional UGPS = ungraded good practice statement Quality of Evidence ⊕⊕⊕⊕ = high ⊕⊕⊕ = moderate ⊕⊕ = low ⊕ = very low

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