Abbreviations
BZA, bazedoxifene; CEE, conjugated equine estrogens; CHD, coronary heart disease;
CI, confidence interval; CVD, cardiovascular disease; DVT, deep vein thrombosis; E,
estrogen; E2, 17-B estradiol; EPT, estrogen plus progestogen therapy; ES, Endocrine
Society; ET, estrogen therapy; GSM, genitourinary syndrome of menopause; HR, hazard
ratio; IBIS, International Breast Intervention Study; IUD, intrauterine device; LNorg,
levonorgestrel; MetS, metabolic syndrome; MHT, menopausal hormone therapy; MI,
myocardial infarction; MPA, medroxyprogesterone acetate; NCI, National Cancer
Institute; Neta, norethindrone acetate or norethisterone acetate; OTC, over the counter;
PE, pulmonary embolism; POI, primary ovarian insufficiency; qd, once daily; QOL,
quality of life; RCT, randomized controlled trial; SERM, selective estrogen receptor
modulator; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin-norepinephrine
reuptake inhibitor; T4, thyroxine; TG, triglycerides; TIA, transient ischemic attack;
TSH, thyroid stimulating hormone; VMS, vasomotor symptoms; VTE, venous
thromboembolism; VVA, vulvovaginal atrophy; WHI, Women's Health Initiative
Source
Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen
RJ. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice
Guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011.
Grading System
Strength of
Recommendation
1 = strong 2 = less strong
US = Ungraded best practice statement
Quality of
Evidence
⊕⊕⊕⊕
= high
⊕⊕⊕
= moderate
⊕⊕
= low
⊕
= very low
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Disclaimer
is Guideline attempts to define principles of practice that should produce high-quality
patient care. It focuses on the needs of primary care practice, but also is applicable to providers
at all levels. is Guideline should not be considered exclusive of other methods of care
reasonably directed at obtaining the same results. e ultimate judgment concerning the
propriety of any course of conduct must be made by the clinician aer consideration of each
individual patient situation.
Neither IGC, the medical associations, nor the authors endorse any product or service
associated with the distributor of this clinical reference tool.
