Treatment
Table 3. Drugs Associated with Weight Gain and
Suggested Alternatives
(Where evidence is mixed or reports are of a few cases, a "?"
has been added.)
Category Drug Class Weight Gain
Alternatives –
weight reducing in
parentheses
Psychiatric Agents Antipsychotic • Clozapine
• Risperidone
• Olanzapine
• Quetiapine
• Haloperidol
• Perphenazine
• Ziprasidone
• Aripiprazole
Antidepressants/
mood stabilizers:
tricyclic
antidepressants
• Amitriptyline
• Doxepin
• Imipramine
• Nortriptyline
• Trimipramine
• Mirtazapine
• (Bupropion)
• Nefazodone
• Fluoxetine
(short term)
• Sertraline
(<1 yr)
Antidepressants/
mood stabilizers:
SSRIs
• Fluoxetine?
• Sertraline?
• Paroxetine
• Fluvoxamine
Antidepressants/
mood stabilizers:
MAO inhibitors
• Phenelzine
• Tranylcypromine
Lithium • N/A
Neurologic Agents Anticonvulsants • Carbamazepine
• Gabapentin
• Valproate
• Lamotrigine?
• (Topiramate)
• (Zonisamide)
Endocrinologic
Agents
Diabetes drugs • Insulin (weight gain
differs with type
and regimen used)
• Sulfonylureas
• Thiazolidinediones
• Sitagliptin?
• Mitiglinide
• (Metformin)
• (Acarbose)
• (Miglitol)
• (Pramlintide)
• (Exenatide)
• (Liraglutide)
Gynecologic Agents Oral contraceptives • Progestational
steroids
• Hormonal
contraceptives
containing
progestational
steroids
• Barrier methods
• IUDs
Endometriosis
treatment
• Depot leuprolide
acetate
• Surgical methods
