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ESHYP1883
Disclaimer
is pocket guide attempts to define principles of practice that should produce high-quality patient
care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels.
is pocket guide should not be considered exclusive of other methods of care reasonably directed at
obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct
must be made by the clinician aer consideration of each individual patient situation.Neither IGC,
the medical associations, nor the authors endorse any product or service associated with the distributor
of this clinical reference tool.
Source
Sklar CA et al. Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood
Cancer: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, July 2018,
103(8):1–24.
Abbreviations
ACTH, adrenocorticotropic hormone; ACTHD, adrenocorticotropic hormone deficiency;
AH, adult height; CNS, central nervous system; CPP, central precocious puberty; CRT,
cranial radiation therapy; CSI, craniospinal irradiation; f T4, free T4; GHD, growth hormone
deficiency; GHT, growth hormone treatment; GnRHa, gonadotropin-releasing hormone
agonist; Gy, Gray; HP, hypothalamic-pituitary; ITT, insulin tolerance test; LH/FSHD,
luteinizing hormone/follicle-stimulating hormone deficiency; RT, radiation treatment; SCFE,
slipped capital femoral epiphysis; TBI, total body irradiation; T2DM, type 2 diabetes mellitus;
TKI, tyrosine kinase inhibitor; TSH, thyroid-stimulating hormone; TSHD, thyroid-stimulating
hormone deficiency
Grading System
Strength of
Recommendation
1 = strong 2 = conditional UGPS = ungraded good
practice statement
Quality of
Evidence
⊕⊕⊕⊕
= high
⊕⊕⊕
= moderate
⊕⊕
= low
⊕
= very low