Endocrine Society GUIDELINES Bundle (free trial)

Pediatric Obesity

Endocrine Society GUIDELINES Apps brought to you free of charge courtesy of Guideline Central. All of these titles are available for purchase on our website, GuidelineCentral.com. Enjoy!

Issue link: https://eguideline.guidelinecentral.com/i/1140160

Contents of this Issue

Navigation

Page 8 of 27

9 a Measure insulin and proinsulin in patients with clinical features of PCSK1 deficiency. Adapted from: August GP et al. J Clin Endocrinol Metab. 2008;93:4576–4599. with permission, ©Endocrine Society. Republished with permission of Springer Science and Bus Media BV from Farooqi S and O'Rahilly S In: Grant S, ed. e Genetics of Obesity. New York, NY: Springer; 2104:23–32.; permission conveyed through Copyright Clearance Center, Inc. Table 3. Genetic Obesity Syndromes With and Without Developmental Delay Genetic Obesity Syndrome Clinical Features Obesity WITH Developmental Delay Dominant Prader-Willi syndrome Hypotonia, failure to thrive in infancy followed by weight gain, short stature (due to GH deficiency), hyperphagia, hypogonadotropic hypogonadism, sleep disturbance, obsessive behaviors Albright's hereditary osteodystrophy Short stature in some but not all patients, skeletal defects, impaired olfaction, and hormone resistance (e.g., parathyroid hormone) if a mutation is maternally inherited SIM1 deficiency Hyperphagia with autonomic dysfunction (characterized by low systolic blood pressure), speech and language delay, neurobehavioral abnormalities, including autistic type behaviors BDNF/TrkB deficiency Hyperactivity, impaired concentration, limited attention span, impaired short-term memory and pain sensation Recessive Bardet-Biedl syndrome Dysmorphic extremities (syndactyly/brachydactyly/polydactyly), retinal dystrophy or pigmentary retinopathy, hypogonadism, renal abnormalities/impairment TUB deficiency Retinal dystrophy, deafness Figure 1. Diagnosis and Management Flowchart —footnotes

Articles in this issue

Archives of this issue

view archives of Endocrine Society GUIDELINES Bundle (free trial) - Pediatric Obesity