Treatment
24
Table 5. Medications Studied for the Long-Term Treatment
of Obesity (cont'd)
Drug Status
Common Side
Effects
Monitoring and
Contraindications
Bupropion plus
naltrexone
a
Approved for
long-term use in
adults
Nausea,
constipation,
headache,
vomiting, dizziness,
insomnia, dry
mouth, diarrhea
Monitor HR, BP.
Do not administer to
patients with a history
of seizure disorders
or with anorexia
or bulimia nervosa
or to patients who
are using opioids or
abruptly discontinuing
use of alcohol,
benzodiazepines,
barbiturates, or
antiseizure medications.
ere is potential
increased risk of
suicidality.
Drugs in development or used off-label that may act centrally as anorexigenic
medications.
Recombinant
human leptin,
metreleptin
a
is drug
is under
investigation. In
monotherapy it
was successful for
treating leptin
deficiency.
Headache,
abdominal pain
is drug is useful only
in leptin deficiency.
Antibodies with
neutralizing activity
have been identified
in patients treated
with metreleptin.
T cell lymphoma
has been reported
in patients with
acquired generalized
lipodystrophy. A
risk evaluation and
mitigation strateg y
should be in place to
prevent inappropriate
prescription.
