23
Table 5. Medications Studied for the Long-Term Treatment
of Obesity (cont'd)
Drug Status
Common Side
Effects
Monitoring and
Contraindications
Lorcaserin
a
Approved for
long-term use in
adults
Headache,
dizziness, fatigue,
nausea, dry
mouth, cough,
and constipation;
back pain, cough,
hypoglycemia
in patients with
T2DM
ere is a risk for serotonin
syndrome or neuroleptic
malignant syndrome-like
reactions. Evaluate patients
for signs or symptoms
of valvular heart disease.
Euphoria, hallucination,
and dissociation have been
seen with supratherapeutic
doses. Interactions with
triptans, MAOIs, including
linezolid, SSRIs, SNRIs,
dextromethorphan, tricyclic
antidepressants, bupropion,
lithium, tramadol,
tryptophan, and St. John's
wort.
Liraglutide
a
Approved for
long-term use in
adults
Nausea, diarrhea,
constipation,
vomiting,
headache, decreased
appetite, dyspepsia,
fatigue, dizziness,
abdominal pain,
increased lipase
Monitor heart rate at regular
intervals. is medication is
contraindicated in patients
with a history of medullary
thyroid carcinoma or in
patients with multiple
endocrine neoplasia
syndrome type 2.
Discontinue promptly if
pancreatitis is suspected.
Phentermine
plus
topiramate
a
Approved for
long-term use in
adults
Paresthesias,
dizziness, taste
alterations,
insomnia,
constipation, dry
mouth, elevation in
heart rate, memory
or cognitive
changes
is medication is
contraindicated in
glaucoma, hyperthyroidism,
MAOIs. Concerns about
teratogenicity (increased
risk of oral cles) mandate
effective contraceptive
use and pregnancy test
monitoring in females.
Metabolic acidosis,
hypokalemia, and elevated
creatinine have been
reported, and periodic
monitoring is advised.
Abrupt withdrawal of
topiramate may cause
seizures.
