8
Diagnosis
Table 2. Very High-Risk
a
of Future ASCVD Events
Major ASCVD Events
Recent ACS (within the past 12 mo)
History of MI (other than recent ACS event listed above)
History of ischemic stroke
Symptomatic peripheral arterial disease (history of claudication with ABI <0.85, or
previous revascularization or amputation)
High-Risk Conditions
Age ≥65 y
Heterozygous familial hypercholesterolemia
History of prior coronary artery bypass surgery or percutaneous coronary intervention
outside of the major ASCVD event(s)
Diabetes mellitus
Hypertension
CKD (eGFR 15-59 mL/min/1.73 m
2
)
Current smoking
Persistently elevated LDL-C (LDL-C ≥100 mg/dL [≥2.6 mmol/L]) despite maximally
tolerated statin therapy and ezetimibe
History of congestive HF
a
Very high-risk includes a history of multiple major ASCVD events or one major ASCVD
event and multiple high-risk conditions.
