Selecting a Treatment Regimen
Figure 2. Cryptococcal
HIV-Infected
Individuals
Alternatives to
Induction Therapy
Induction Therapy
AmBd (0.7-1.0 mg/kg per day)
plus flucytosine
(100 mg/kg per day)a
Duration: 2 weeks (A-I)
OR
Lipsomosal AmB
(3-4 mg/kg per day) or ABLC (5
mg/kg per day, with renal function
concerns) plus flucytosine
(100 mg/kg per day)a
Duration: 2 weeks (B-II)
AmBd plus Fluconazole
(B-I)
OR
Fluconazole plus flucytosine
(B-II)
OR
Fluconazole
(B-II)
OR
Itraconazole
(C-II)
OR
AmBd (0.7-1.0 mg/kg per day) or
liposomal AmB (3-4 mg/kg per
day) or ABLC (5 mg/kg per day,
for flucytosine-intolerant patients)
Duration: 4-6 weeks (B-II)
Consolidation
Fluconazole
(400 mg per day)
Duration: 8 weeks (A-I)
Maintenance
Fluconzole (200 mg per day)a
Duration: ≥ 1 yearc (A-I)
Alternatives for
Maintenance Therapyb
Itraconazole
(400 mg per day)d
Duration: ≥ 1 yearc (C-I)
OR
AmBd (1 mg/kg per week)d
Duration: ≥ 1 yearc (C-I)
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