11
Table 5. Bioequivalence of Buprenorphine Formulations
Available Dosage Strengths
Buprenorphine sublingual tablets,
including generic equivalents:
2 mg buprenorphine
8 mg buprenorphine
Buprenorphine and naloxone sublingual
tablets, including generic equivalents:
2 mg buprenorphine/ 0.5 mg naloxone
8 mg buprenorphine / 2 mg naloxone
Zubsolv
®
(Buprenorphine and naloxone
sublingual tablets):
1.4 mg buprenorphine / 0.36 mg naloxone
2.9 mg buprenorphine / 0.7 mg naloxone
5.7 mg buprenorphine / 1.4 mg naloxone
8.6 mg buprenorphine / 2.1 mg naloxone
11.4 mg buprenorphine / 2.6 mg naloxone
Suboxone
®
sublingual film
(Buprenorphine and naloxone
sublingual film):
2 mg buprenorphine / 0.5 mg naloxone
4 mg buprenorphine / 1 mg naloxone
8 mg buprenorphine / 2 mg naloxone
12 mg buprenorphine / 3 mg naloxone
Bunavail
®
(Buprenorphine
hydrochloride and naloxone
hydrochloride buccal film):
2.1 mg buprenorphine / 0.3 mg naloxone
4.2 mg buprenorphine / 0.7 mg naloxone
6.3 mg buprenorphine / 1 mg naloxone
Corresponding doses of buprenorphine products that contain naloxone
Buprenorphine
and naloxone
sublingual tablets,
including generic
equivalents
Suboxone
®
sublingual films
Zubsolv
®
sublingual tablets
Bunavail
®
buccal films
2 mg
buprenorphine /
0.5 mg naloxone
2 mg
buprenorphine /
0.5 mg naloxone
1. 4 mg
buprenorphine /
0. 36 mg naloxone
4 mg
buprenorphine /
1 mg naloxone
2 .9 mg
buprenorphine /
0.71 mg naloxone
2 .1 mg
buprenorphine /
0. 3 mg naloxone
8 mg
buprenorphine /
2 mg naloxone
8 mg
buprenorphine /
2 mg naloxone
5. 7 mg
buprenorphine /
1. 4 mg naloxone
4. 2 mg
buprenorphine /
0. 7 mg naloxone
12 mg
buprenorphine /
3 mg naloxone
8. 6 mg
buprenorphine /
2 .1 mg naloxone
6 . 3 mg
buprenorphine /
1 mg naloxone
11.4 mg
buprenorphine /
2 .9 mg naloxone
Adapted from: Office-Based Buprenorphine erapy for Opioid Dependence: Important
Information for Prescribers. Available at: https://www.btodrems.com
