Diagnostic Criteria
����Chronic hepatitis B
������ HBsAg-positive > 6 months
������ Serum HBV DNA > 20,000 IU/mL (105 copies/mL).
Lower values ��� 2,000-20,000 IU/mL (104-105 copies/mL) ��� are often seen in
HBeAg-negative chronic hepatitis B
������ Persistent or intermittent elevation in alanine aminotransferase/aspartate
aminotransferase (ALT/AST) levels
������ Liver biopsy showing chronic hepatitis with moderate or severe
necroinflammation
����Inactive HBsAg carrier state
������ HBsAg-positive > 6 months
������ HBeAg(���), anti-HBe(+)
������ Serum HBV DNA < 2,000 IU/mL
������ Persistently normal ALT/AST levels
������ Liver biopsy confirms absence of significant hepatitis
����Resolved hepatitis B
������ Previous known history of acute or chronic hepatitis B or the presence of ���
hepatitis B core antibody (anti-HBc) �� hepatitis B surface antibody (anti-HBs)
������ HBsAg(���)
������ Undetectable serum HBV DNA*
������ Normal ALT levels
*Very low levels may be detectable using sensitive polymerase chain reaction (PCR) assays.
1
