HBeAg-Positive Patients
��Perform ALT test at 3-6 month intervals for HBeAg-positive patients
��
with persistently normal ALT. When ALT levels become elevated, test
more often for ALT along with HBV DNA. Check HBeAg status every 6-12
months. (III)
����Consider for liver biopsy patients who remain HBeAg positive with
HBV DNA levels > 20,000 IU/mL after a 3-6 month period of elevated
ALT levels between 1-2 �� ULN, or who remain HBeAg positive with
HBV DNA levels > 20,000 IU/mL and are > 40 years old.
������ Consider treatment if biopsy shows moderate/severe inflammation or significant
fibrosis. (III)
����Consider for treatment patients who remain HBeAg positive with HBV
DNA levels > 20,000 IU/mL after a 3-6 month period of elevated ALT
levels 2 �� ULN. (III)
HBeAg-Negative Patients
����HBeAg-negative patients with normal ALT and HBV DNA < 2,000 IU/mL
should be tested for ALT every 3 months during the first year to verify
that they are truly in the ���inactive carrier state��� and then every
6-12 months. (III)
����Perform tests for HBV DNA and initiate more frequent monitoring if
ALT or AST increases above the normal limit. (III)
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