AASLD GUIDELINES Bundle (free trial)

Hepatitis B

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Issue link: https://eguideline.guidelinecentral.com/i/100168

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Diagnostic Criteria ����Chronic hepatitis B ������ HBsAg-positive > 6 months ������ Serum HBV DNA > 20,000 IU/mL (105 copies/mL). Lower values ��� 2,000-20,000 IU/mL (104-105 copies/mL) ��� are often seen in HBeAg-negative chronic hepatitis B ������ Persistent or intermittent elevation in alanine aminotransferase/aspartate aminotransferase (ALT/AST) levels ������ Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation ����Inactive HBsAg carrier state ������ HBsAg-positive > 6 months ������ HBeAg(���), anti-HBe(+) ������ Serum HBV DNA < 2,000 IU/mL ������ Persistently normal ALT/AST levels ������ Liver biopsy confirms absence of significant hepatitis ����Resolved hepatitis B ������ Previous known history of acute or chronic hepatitis B or the presence of ��� hepatitis B core antibody (anti-HBc) �� hepatitis B surface antibody (anti-HBs) ������ HBsAg(���) ������ Undetectable serum HBV DNA* ������ Normal ALT levels *Very low levels may be detectable using sensitive polymerase chain reaction (PCR) assays. 1

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