Treatment
Table 6. Adult Dosage of Nucleoside Analogue in
Accordance with Creatinine Clearance (ClCr)
Drug
Entecavir
ClCr
(mL/min)
(lamivudine
Adefovir Entecavir
refractory/ Lamivudine Telbivudine Tenofovir
Hepsera �� Baraclude �� resistant) Epivir ��
Tyzeka ��
Viread ��
0.5 mg qd
(I)
��� 50
10 mg
daily (I)
30-49
10 mg
0.25 mg qd
every
or 0.5 mg ���
other day q 48 hr
1 mg qd (I)
100 mg
qd (I)
600 mg ���
300 mg ���
once daily (I) q 24 hr (I)
0.5 mg qd
or 1 mg ���
q 48 hr
100 mg first
dose, then
50 mg qd
600 mg ���
once every
48 hr
15-29
100 mg first
dose, then
25 mg qd
0.15 mg qd
or 0.5 mg ���
q 72 hr
10-29
10-19
0.3 mg qd
or 1 mg ���
q 72 hr
35 mg first
dose, then
15 mg qd
0.05 mg qd
or 0.5 mg ���
q 7 days
< 10
10
(Without
dialysis)
No recommendation
35 mg first
dose, then
10 mg qd
10 mg
every
week
following
dialysis
0.05 mg qd
or 0.5 mg ���
q 7 days
End-stage
renal disease
a
(Not
requiring
dialysis)
600 mg ���
once every
72 hr
0.1 mg qd
or 1 mg ���
q 7 days
<5
Hemodialysisa
or continuous
ambulatory
peritoneal
dialysis
300 mg ���
q 72-96 hr
10 mg
every
third day
5-14
Hemodialysis
patients
300 mg ���
q 48 hr
Administer after hemodialysis.
0.1 mg qd
or 1 mg ���
q 7 days
300 mg once
a week or
after a total of
approximately
12 hr of
dialysis
600 mg ���
once every
96 hra
