Table 1. Some Drugs Which May Cause Idiosyncratic Liver
Injury Leading to Acute Liver Failure
Isoniazid
Pyrazinamide
Sulfasalazine
Isoflurane
Phenytoin
Itraconazole
Statins
Nicotinic acid
Propylthiouracil
Imipramine
Ciprofloxacin
Gemtuzumab
Nitrofurantoin
Terbinafine
Disulfiram
Methyldopa
Cocaine
MDMA (Ecstasy)
Valproic acid
Labetalol
Amiodarone
Tolcapone
Dapsone
Allopurinol
Etodolac
Methyldopa
Didanosine
Ketoconazole
Efavirenz
Abacavir
Carbamazepine
Doxycycline
Valproic Acid
Diclofenac
Combination agents with enhanced toxicity:
Trimethoprim-sulfamethoxazole
Rifampin-Isoniazid
Amoxicillin-clavulanate
Some herbal products/dietary supplements that have been associated with
hepatotoxicity include:
Kava Kava
Greater celandine
Herbalife
He Shon Wu
Hydroxycut
LipoKinetix
Comfrey
Ma Huang
Senecio
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