AASLD GUIDELINES Bundle (free trial)

Acute Liver Failure

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Levels of Evidence According to Study Design Grade Definition I II-1 II-2 Randomized controlled trials Controlled trials without randomization Cohort or case control analytic studies II-3 Multiple time series Dramatic uncontrolled experiments Opinion of respected experts Descriptive epidemiology III Abbreviations AFP, alpha fetoprotein; ALF, acute liver failure; Bx, biopsy; CPP, cerebral perfusion pressure; CT, computerized tomography; CVVHD, continuous venovenous hemodialysis; DILI, Drug Induced Liver Injury; Dx, diagnosis; FFP, fresh frozen plasma; GI, gastrointestinal; gm/day, grams per day; gm/kg, grams per kilogram; H2, histamine-2; HBV, hepatitis b virus; HELLP, Hemolysis, Elevated Liver Enzymes, Low Platelets syndrome; ICH, intracranial hypertension; ICP, intracranial pressure; ICU, intensive care unit; INR, international normalized ratio; IU/L, international units per liter; MAP, mean arterial pressure; MELD, Model for End-stage Liver Disease; mg/dL, milligrams per deciliter; mg/kg, milligrams per kilogram; NA, nucleoside/nucleotide analogue; NAC, N-acetylcysteine; OLT, orthotopic liver transplantation; OTC, over the counter; PPI, proton pump inhibitors; rFVIIa, recombinant activated factor VII; Rx, treatment; SIRS, systemic inflammatory response syndrome; SQ, subcutaneous; US ALFSG, United States Acute Liver Failure Study Group Source Lee WM, Larson AM, Stravitz RT. AASLD position paper: the management of acute liver failure: update 2011. Hepatol. 2011; available at: http://www.aasld.org/ practiceguidelines/Documents/AcuteLiverFailureUpdate2011.pdf Disclaimer This Guideline attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician after consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. ACU10122c 5740 Executive Drive��� Suite 218 Baltimore, MD 21228��� TEL: 410-869-3332��� ������ FAX: 410-744-2150��� For additional copies: orders@GuidelineCentral.com Copyright �� 2012 All rights reserved

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