ASCO GUIDELINES Bundle

Breast Cancer Biomarkers

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2017 All rights reserved Disclaimer is pocket card is derived om recommendations in the American Society of Clinical Oncolog y Guideline. is resource is a practice tool based on ASCO ® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket card does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at www.asco.org/breast-cancer- guideline. Copyright © 2017 by American Society of Clinical Oncolog y. All rights reserved. ASCOBIO17072c Abbreviations ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; PR, progesterone receptor; PTEN, phosphatase and tensin homolog ; RS, recurrence score; TN, triple negative Source Krop I et al. Use Of Biomarkers To Guide Decisions On Adjuvant Systemic erapy For Women With Early-Stage Invasive Breast Cancer: Focused Update of 2016 American Society of Clinical Oncolog y Clinical Practice Guideline. J Clin Oncol. 2017 July 10; doi: 10.1200/ JCO.2017.74.0472 Harris LN, Ismaila N, McShane LM, Andre F, Collyar DE, Gonzalez-Angulo AM, Hammond EH, Kuderer NM, Liu MC, Mennel RG, Van Poznak C, Bast RC, Hayes DF; American Society of Clinical Oncolog y. Use of Biomarkers to Guide Decisions on Adjuvant Systemic erapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncolog y Clinical Practice Guideline. J Clin Oncol. 2016 Apr 1;34(10):1134-50. Van Poznak C, Somerfield MR, Bast RC, Cristofanilli M, Goetz MP, Gonzalez-Angulo AM, Hicks DG, Hill EG, Liu MC, Lucas W, Mayer IA, Mennel RG, Symmans WF, Hayes DF, Harris LN. erapy for Women With Metastatic Breast Cancer: American Society of Clinical Oncolog y Clinical Practice Guideline. J Clin Oncol. 2015 Aug 20;33(24):2695-704. ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, patient versions, frequently asked questions, and other clinical tools and resources, is available at www.asco.org/breast-cancer-guidelines and www.asco.org/guidelineswiki Recommendation Grading Type Evidence Quality Strength of Recommendation EB Evidence-based H High Strong IC Informal consensus I Intermediate Moderate L Low Weak Ins Insufficient

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