Overview of Local Analgesics Table. Onset and Duration of Local Analgesic Action*
Onset (min)
Lidocaine
Bupivacaine Mepivacaine
Ropivacaine
Bupivacaine liposome injectable suspension19
5 < 5 5 < 5
Duration (hr)
½-1 ~3-6 ¾-1½ 1½-3 Up to 72
Prolongation With
Epinephrine ++
+/− ++
+/− N/A
Toxic Dose With Single Administration
(7 mg/kg with epinephrine)
4-5 mg/kg
(7 mg/kg with epinephrine)
1.7-2 mg/kg 4-5 mg/kg
3 mg/kg
Safety data up to 532 mg
(266 mg per surgical site)
Key: ++, significant potentiation; +/−, some potentiation; N/A, not applicable. *Adapted from Sinatra et al. Surgeon's Guide to Postsurgical Pain Management.20
Educational Videos
ÎTo enhance the local analgesic infiltration techniques described and illustrated in this PocketGuide, members of the Working Group have provided narrated videos of the techniques. These are coming soon - click here to receive updates.
Disclaimer
This PocketGuide attempts to define principles of practice that should produce high-quality patient care. It should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aſter consideration of each individual patient situation. The views and opinions contained in this PocketGuide are those of the contributors and are not approved or endorsed by affiliated institutions or associations. Neither IGC, medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool.
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