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Anaphylaxis 2016

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27 Strength of Evidence A Directly based on category I evidence that is well designed B Directly based on category II evidence or recommendation from category I evidence that is not well designed C Directly based on category III evidence or recommendation from category II evidence that is not well designed D Directly based on category IV or recommendation from category III evidence that is not well designed LB Laboratory based NR Not Rated Category of Evidence Ia Evidence from meta-analysis of randomized controlled trials Ib Evidence from at least one randomized controlled trial Ic Evidence from at least 1 randomized controlled trial that was not very well designed IIa Evidence from at least one controlled study without randomization IIb Evidence from at least one other type of quasi-experimental study IIc Evidence from one of the above that was not very well designed IIIa Evidence from well-designed nonexperimental descriptive studies, such as comparative studies IIIb Evidence from nonexperimental descriptive studies, such as comparative studies, that were not very well designed IVa Evidence from expert committee reports and/or opinions or clinical experience of respected authorities

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