Disclaimer
is Guideline attempts to define principles of practice that should produce high-quality patient
care. It is applicable to specialists, primary care, and providers at all levels. is Guideline
should not be considered exclusive of other methods of care reasonably directed at obtaining the
same results. e ultimate judgment concerning the propriety of any course of conduct must be
made by the clinician aer consideration of each individual patient situation.
Neither IGC, the medical associations, nor the authors endorse any product or service associated
with the distributor of this clinical reference tool.
Abbreviations
CA, community-associated; CO-HCFA, community-onset healthcare facility-associated;
CXR, chest radiograph; EIA, enzyme immunoassays; GDH, glutamate dehydrogenase;
HIV, human immunodeficiency virus; HO-CDI, healthcare facility-onset C. difficile
infection; HPLC, high-performance liquid chromatography; IGRA, interferon-γ
release assay; IV, intravenous; LTBI, latent tuberculosis infection; Mtb, Mycobacterium
tuberculosis; NAAT, nucleic acid amplification test; PO, by mouth; PPI, proton pump
inhibitors; PR, per rectum; RCT, randomized clinical trial; RR, relative risk; TB,
tuberculosis; TST, tuberculin skin test
e guidelines provide evidence-based recommendations that have been developed
using GR ADE (Grading of Recommendations, Assessment, Development, and
Evaluation) methodolog y. GR ADE involves structured literature review, systematic
reviews and meta-analyses of combined data, and expert discussion to assess the
certainty in the evidence and determine the strength of each recommendation.
Source
McDonald LC et al. Clinical Practice Guidelines for Clostridium difficile Infection in
Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA)
and Society for Healthcare Epidemiolog y of America (SHEA).
e guidelines were endorsed by the American Society for Health Systems Pharmacists
(ASHP), the Society of Infectious Diseases Pharmacists (SIDP), and the Pediatric
Infectious Diseases Society (PIDS)
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