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Prevention of Stroke in Women

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Table 2. Summary of Antihypertensive Drugs Used During Pregnancy Category Maternal Side Effects Teratogenicity or Fetal-Neonatal Adverse Effects Class/Level of Evidence Centrally acting α2- adrenergic agonist (eg, methyldopa) Sedation, elevated LFTs, depression No IIa-C Diuretics (thiazide) Hypokalemia No III-B β-Blockers (atenolol Headache Associated with fetal growth restriction III-B β-Blockers (pindolol, metoprolol) Headache Possible fetal growth restriction, neonatal bradycardia IIa-B Calcium channel blockers (eg, nifedipine) Headache; possible interaction with magnesium sulfate; may interfere with labor No I-A Combined α-β blockers (labetalol) May provoke asthma exacerbation Possible neonatal bradycardia IIa-B Hydralazine Reflex tachycardia, delayed hypotension Neonatal thrombocytopenia, fetal bradycardia III-B ACE inhibitors, angiotensin receptor blockers, renin inhibitors Skeletal and cardiovascular abnormalities, renal dysgenesis, pulmonary hypoplasia III-C Modified from Umans JG, Abalos EJ, Lindheimer MD. Antihypertensive treatment. In: Lindheimer MD, Roberts JM, Cunningham FG, eds. Chesly's Hypertensive Disorders in Pregnancy. Amsterdam: Academic Press, Elsevier; 2009:369–338. With permission from Elsevier, Copyright © 2009.

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