Treatment
16
Table 7. Statin Therapy
Intensity Definition Dosage
Low Daily dose lowers LDL-C by <30%,
on average
Simvastatin 10 mg
Pravastatin 10–20 mg
Lovastatin 20 mg
Fluvastatin 20–40 mg
Pitavastatin 1 mg
Moderate Daily dose lowers LDL-C by
approximately 30% to <50% on
average
Atorvastatin 10–20 mg
Rosuvastatin 5–10 mg
Simvastatin 20–40 mg
Pravastatin 40–80 mg
Lovastatin 40 mg
Fluvastatin XL 80 mg
Fluvastatin 40 mg bid
Pitavastatin 2–4 mg
High Daily dose lowers LDL-C by
approximately ≥50%, on average
Atorvastatin 40–80 mg
Rosuvastatin 20–40 mg
Table 8. Treatment Recommendations and LDL-C Goals
for Treatment
Primary prevention Statin treatment
LDL-C goal or
% reduction
Adults with LDL-C ≥190 mg/dL
(≥4.9 mmol/L)
High intensity ≥50% reduction of LDL-C
Individuals 40–75 years of age
without diabetes and LDL-C
70–189 mg/dL (1.8–4.9 mmol/L)
and a 10-year risk ≥7.5%
Moderate or high
intensity
<100 mg/dL (<5.6
mmol/L) or ≥50%
reduction of LDL-C
Individuals 40–75 years of age
without diabetes and LDL-C
70–189 mg/dL (1.8–4.9 mmol/L)
and a 10-year risk of 5 to <7.5%
Consider moderate
intensity
<130 mg/dL (<3.4
mmol/L) or 30–50%
reduction of LDL-C
Individuals aged >75 years
without diabetes and LDL-C
70–189 mg/dL (1.8–4.9 mmol/L)
and a 10-year risk ≥7.5%
Consider first low
intensity, aer
discussion with the
patient
<130 mg/dL (<3.4
mmol/L) or 30–50%
reduction of LDL-C
* ASCVD risk factors include LDL-C ≥100 mg/dL (2.6 mmol/L), high blood pressure, smoking,
chronic kidney disease, albuminuria, and family history of premature ASCVD.
