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Cardiac Physiologic Pacing for the Avoidance and Mitigation of Heart Failure

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3 8. CRT remains recommended for patients with HF, LVEF ≤35%, LBBB, QRS duration ≥ 150 ms, and New York Heart Association (NYHA) class II–IV symptoms on guideline-directed medical therapy (COR 1). New recommendations are made for CSP when effective CRT cannot be achieved (COR 2a); and for CRT in patients with select characteristics (eg, female sex), as they may derive benefit from CRT at QRS durations of 120–149 ms (COR 1). New recommendations are also made for patients with HF, LVEF 36%– 50%, LBBB, and QRS duration ≥ 150 ms for CRT or CSP to maintain or improve LVEF (COR 2b). 9. New CPP recommendations are provided for patients with HF, LVEF ≤ 35%, and non-LBBB pattern for QRS duration both < 150 and ≥ 150 ms (COR 2b). 10. During implantation and follow-up of patients with CPP devices, electrocardiographic demonstration of BiV (for CRT) or conduction system (for CSP) capture is essential.

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