Endocrine Society GUIDELINES Bundle (free trial)

106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2022 All rights reserved ESHYPERG04223 Disclaimer is pocket guide attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice but also is applicable to providers at all levels. is pocket guide should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. Source Korytkowski MT, Muniyappa R, Antinori-Lent K, et al. Management of Hyperglycemia in Hospitalized Adult Patients in Non-Critical Care Settings: An Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab. 2022, 107(8). Table 4. GRADE Classification of Guideline Recommendations Certainty of Evidence Interpretation High ⊕⊕⊕⊕ We are very confident that the true effect lies close to that of the estimate of the effect. Moderate ⊕⊕⊕ We are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low ⊕⊕ Our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect. Very Low ⊕ We have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect. Reprinted from Eds. Schünemann H, Brożek J, Guyatt G, and Oxman A. GRADE Handbook: Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. Updated October 2013. Table 5. GRADE Strength of Recommendation Classifications and Interpretation Strength of recommendation Criteria Interpretation by patients Interpretation by health care providers Interpretation by policy makers 1 – Strong recommendation for or against Desirable consequences CLEARLY OUTWEIGH the undesirable consequences in most settings (or vice versa). Most individuals in this situation would want the recommended course of action, and only a small proportion would not. Most individuals should receive the recommended course of action. Adherence to this recommendation according to the guidelines could be used as a quality criterion or performance indicator. Formal decision aids are not likely to be needed to help individuals make decisions consistent with their values and preferences. The recommendation can be adopted as policy in most situations. 2 – Conditional recommendation for or against Desirable consequences PROBABLY OUTWEIGH undesirable consequences in most settings (or vice versa). The majority of individuals in this situation would want the suggested course of action, but many would not. Clinicians should recognize that different choices will be appropriate for each individual and that clinicians must help each individual arrive at a management decision consistent with the individual's values and preferences. Decision aids may be useful to help individuals make decisions consistent with their values and preferences. Policy-making will require substantial debate and involvement of various stakeholders. Adapted from Schünemann HJ et al. Blood Adv, 2018; 2(22) © by e American Society of Hematolog y.

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