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ASCOESO08214a
Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncology
Guideline. is resource is a practice tool based on ASCO
®
practice guidelines and is not intended
to substitute for the independent professional judgment of the treating physician. Practice guidelines
do not account for individual variation among patients. is pocket guide does not purport to
suggest any particular course of medical treatment. Use of the practice guidelines and this resource
are voluntary. e practice guidelines and additional information are available at www.asco.org/
gastrointestinal-cancer-guidelines. Copyright © 2021 by American Society of Clinical Oncology.
All rights reserved.
Abbreviations
CPS, combined positive score; CRT, chemoradiotherapy; CT, chemotherapy; PD-L1,
programmed death-ligand 1; RT, radiotherapy
Source
Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; et al. Treatment of
Locally Advanced Esophageal Carcinoma: ASCO Guideline. J Clin Oncol. 2021 July 28 doi:
10.1200/JCO.21.01831
Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; Dana C. Deighton;
Karyn A. Goodman, MD; Narinder K. Malhotra, MD; Christopher Willett, MD; Brendon
Stiles, MD; Prateek Sharma, MD; Laura Tang, MD PhD; Bas P.L. Wijnhoven, MD, PhD;
Wayne Hofstetter, MD. Treatment of Locally Advanced Esophageal Carcinoma: ASCO
Guideline. J Clin Oncol. 2020 June 22 doi: 10.1200/JCO.20.00866
Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-
based
B Benefits
outweigh harms
H High Strong
CB
Consensus-
based
H Harms outweigh
benefits
M Moderate
IC Informal
consensus
B/H Relative balance
of benefits and
harms
L Low Weak
VL Very Low
Brozek JL, Akl EA, Compalati E, et al: Grading quality of evidence and strength of recommendations in
clinical practice guidelines part 3 of 3. e GRADE approach to developing recommendations. Allerg y
66:588-95, 2011
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical tools
and resources, is available at www.asco.org/gastrointestinal-cancer-guidelines.