ASCO GUIDELINES Bundle

Treatment of Locally Advanced Esophageal Carcinoma

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 For additional copies, order at GuidelineCentral.com Copyright © 2021 All rights reserved ASCOESO08214a Disclaimer is pocket guide is derived om recommendations in the American Society of Clinical Oncology Guideline. is resource is a practice tool based on ASCO ® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at www.asco.org/ gastrointestinal-cancer-guidelines. Copyright © 2021 by American Society of Clinical Oncology. All rights reserved. Abbreviations CPS, combined positive score; CRT, chemoradiotherapy; CT, chemotherapy; PD-L1, programmed death-ligand 1; RT, radiotherapy Source Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; et al. Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline. J Clin Oncol. 2021 July 28 doi: 10.1200/JCO.21.01831 Manish A. Shah, MD; Erin B. Kennedy, MHSc; Dan Catenacci, MD; Dana C. Deighton; Karyn A. Goodman, MD; Narinder K. Malhotra, MD; Christopher Willett, MD; Brendon Stiles, MD; Prateek Sharma, MD; Laura Tang, MD PhD; Bas P.L. Wijnhoven, MD, PhD; Wayne Hofstetter, MD. Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline. J Clin Oncol. 2020 June 22 doi: 10.1200/JCO.20.00866 Recommendation Grading Type Benefit/harm Evidence Quality Strength of Recommendation EB Evidence- based B Benefits outweigh harms H High Strong CB Consensus- based H Harms outweigh benefits M Moderate IC Informal consensus B/H Relative balance of benefits and harms L Low Weak VL Very Low Brozek JL, Akl EA, Compalati E, et al: Grading quality of evidence and strength of recommendations in clinical practice guidelines part 3 of 3. e GRADE approach to developing recommendations. Allerg y 66:588-95, 2011 ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, and other clinical tools and resources, is available at www.asco.org/gastrointestinal-cancer-guidelines.

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