ASCO GUIDELINES Bundle

Treatment for Brain Metastases

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2021 All rights reserved. ASCOBRA10212a Disclaimer is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y Guideline. is resource is a practice tool based on ASCO® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at www.asco.org/neurooncolog y- guidelines. Copyright © 2021 by American Society of Clinical Oncolog y. All rights reserved. Recommendation Grading Type Benefit/harm Evidence Quality Strength of Recommendation EB Evidence-based B Benefits outweigh harms H High Strong CB/ FC Consensus- based/Formal Consensus H Harms outweigh benefits M Moderate Moderate IC Informal consensus B/H Relative balance of benefits and harms L Low Weak N No recommendation U Benefits/ harms ratio uncertain Ins Insufficient Abbreviations ALK, anaplastic lymphoma kinase; EGFR, epidermal growth factor receptor; FDA, US Food & Drug Administration; KPF, Karnofsky performance status; LITT, laser interstitial thermal therapy; NSCLC, non-small-cell lung cancer; PD-L1, Programmed Death-Ligand 1; SRS, stereotactic radiosurgery; WBRT, whole-brain radiotherapy Source Vogelbaum MA, Brown PD, Messersmith H, et al. Treatment for Brain Metastases: ASCO/SNO/ASTRO Guideline. J Clin Oncol. 2021 Dec 21. doi: 10.1200/JCO.21.02314 ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, and other clinical tools and resources, is available at www.asco.org/neurooncolog y-guidelines.

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