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Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y Guideline.
is resource is a practice tool based on ASCO
®
practice guidelines and is not intended to substitute for
the independent professional judgment of the treating physician. Practice guidelines do not account for
individual variation among patients. is pocket guide does not purport to suggest any particular course of
medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and
additional information are available at www.asco.org/head-neck-cancer-guidelines. Copyright ©2020 by
American Society of Clinical Oncolog y. All rights reserved.
Source
Ellie Maghami, Nofisat Ismaila, Adriana Alvarez, Rebecca Chernock, Umamaheswar Duvvuri, Jessica
Geiger, Neil Gross, Bruce Haughey, Doru Paul, Cristina Rodriguez, David Sher; Hilda E. Stambuk; John
Waldron, Matt Witek, James Caudell. Diagnosis and Management of Squamous Cell Carcinoma of
Unknown Primary in the Head and Neck: ASCO Guideline. J Clin Oncol. 2020 April 23 doi: 10.1200/
JCO.20.00275
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Order additional copies at GuidelineCentral.com
Copyright © 2020 All rights reserved
ASCOSCC4203
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical
tools and resources, is available at www.asco.org/head-neck-cancer-guidelines.
Abbreviations
AJCC, American Joint Committee on Cancer; ASCO, American Society of Clinical Oncology; CECT,
contrast enhanced CT of the neck; CT, computed tomography; CUP, carcinoma of unknown primary;
EBER, EBV encoded early RNA; EBV, Epstein-Barr virus; ENE, extranodal extension; HPV, human
papillomavirus; HR, high-risk; PET-CT, positron emission tomography-computed tomography;
SCCUP, squamous cell carcinoma of unknown primary
Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-
based
B Benefits
outweigh harms
H High Strong
FC
Formal
consensus
H Harms outweigh
benefits
I Intermediate Moderate
IC Informal
consensus
B/H Relative balance
of benefits and
harms
L Low Weak
Ins Insufficient
