ASCO GUIDELINES Bundle

Squamous Cell Carcinoma of Unknown Primary Head and Neck

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12 Disclaimer is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y Guideline. is resource is a practice tool based on ASCO ® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at www.asco.org/head-neck-cancer-guidelines. Copyright ©2020 by American Society of Clinical Oncolog y. All rights reserved. Source Ellie Maghami, Nofisat Ismaila, Adriana Alvarez, Rebecca Chernock, Umamaheswar Duvvuri, Jessica Geiger, Neil Gross, Bruce Haughey, Doru Paul, Cristina Rodriguez, David Sher; Hilda E. Stambuk; John Waldron, Matt Witek, James Caudell. Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck: ASCO Guideline. J Clin Oncol. 2020 April 23 doi: 10.1200/ JCO.20.00275 106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2020 All rights reserved ASCOSCC4203 ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, and other clinical tools and resources, is available at www.asco.org/head-neck-cancer-guidelines. Abbreviations AJCC, American Joint Committee on Cancer; ASCO, American Society of Clinical Oncology; CECT, contrast enhanced CT of the neck; CT, computed tomography; CUP, carcinoma of unknown primary; EBER, EBV encoded early RNA; EBV, Epstein-Barr virus; ENE, extranodal extension; HPV, human papillomavirus; HR, high-risk; PET-CT, positron emission tomography-computed tomography; SCCUP, squamous cell carcinoma of unknown primary Recommendation Grading Type Benefit/harm Evidence Quality Strength of Recommendation EB Evidence- based B Benefits outweigh harms H High Strong FC Formal consensus H Harms outweigh benefits I Intermediate Moderate IC Informal consensus B/H Relative balance of benefits and harms L Low Weak Ins Insufficient

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