Key Points
➤ Lung cancers are the leading cause of cancer-related deaths for men and
women throughout the world. In the United States, approximately 237,000
new cases of lung cancer are expected in 2022, and more than 130,000
individuals are expected to die as a result of the disease.
a
➤ Five-year survival rates range from 67% for T1N0 disease to 23% for
patients with in T1-3N2 disease.
➤ Adenocarcinomas and squamous cell lung cancers, which are the focus of
this guideline, comprise approximately 82% of all lung cancers.
b
a
American Cancer Society: Key Statistics for Lung Cancer 2022. https://www.cancer.org/
cancer/lung-cancer/about/key-statistics.html
b
American Cancer Society: Cancer Facts and Figures, 2022. Atlanta, GA, American Cancer
Society, 2022.
Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-based B Benefits
outweigh
harms
H High Strong
CB/
FC
Consensus-
based/Panel
Consensus
H Harms
outweigh
benefits
M Moderate Moderate
IC Informal
consensus
B/H Relative
balance of
benefits
and harms
I Intermediate Weak
N No
recommendation
U Benefits/
harms
ratio
uncertain
Ins Insufficient
