Noncastrate Advanced, Recurrent or Metastatic Prostate Cancer Initial Management

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106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at Copyright © 2021 All rights reserved ASCOPROS01213b Disclaimer is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y Guideline. is resource is a practice tool based on ASCO® practice guidelines and is not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients. is pocket guide does not purport to suggest any particular course of medical treatment. Use of the practice guidelines and this resource are voluntary. e practice guidelines and additional information are available at cancer-guidelines. Copyright © 2021 by American Society of Clinical Oncolog y. All rights reserved. Abbreviations ADT, androgen deprivation therapy; CADT, continuous androgen deprivation therapy; HVD, high-volume disease; IADT, intermittent androgen deprivation therapy; LVD, low-volume metastatic disease; OS, overall survival; PSA, prostate-specific antigen; rPFS, radiographic progression-free survival; RP, radical prostatectomy; RT, radiotherapy; SOC, standard of care Source Virgo KS, et al. Initial Management of Non-Castrate Advanced, Recurrent or Metastatic Prostate Cancer: ASCO Guideline Update. J Clin Oncol. 2021 January 26. doi: 10.1200/ JCO.20.03256. Recommendation Grading Type Benefit/harm Evidence Quality Strength of Recommendation EB Evidence-based B Benefits outweigh harms H High Strong CB/ FC Consensus- based/Formal Consensus H Harms outweigh benefits I Intermediate Moderate IC Informal consensus B/H Relative balance of benefits and harms L Low Weak N No recommendation U Benefits/ harms ratio uncertain Ins Insufficient ASCO believes that cancer clinical trials are vital to inform medical decisions and improve cancer care and that all patients should have the opportunity to participate. Additional information, which may include data supplements, slide sets, and other clinical tools and resources, is available at

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