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ASCOCART08213
Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y
Guideline. is resource is a practice tool based on ASCO
®
practice guidelines and is not intended
to substitute for the independent professional judgment of the treating physician. Practice guidelines
do not account for individual variation among patients. is pocket guide does not purport to
suggest any particular course of medical treatment. Use of the practice guidelines and this resource
are voluntary. e practice guidelines and additional information are available at www.asco.org/
supportive-care-guidelines. Copyright © 2021 by American Society of Clinical Oncolog y.
All rights reserved.
Source
Santomasso BD, Nastoupil LJ, Adkins S, et al. Management of Immune-related Adverse
Events in Patients Treated with Chimeric Antigen Receptor (CAR) T-Cell erapy:
ASCO Guideline . J Clin Oncol. 2021.
Abbreviations
ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST,
aspartate aminotransferase; ASTCT, American Society of Transplantation and Cellular
erapy; ATG, antithymocyte globulin; CAPD, Cornell Assessment of Pediatric Delirium;
CAR T, chimeric antigen receptor T; BiPAP, bilevel positive airway pressure; CBC,
complete blood count; CD4, cluster of differentiation; CMP, comprehensive metabolic
panel; CMV, cytomegalovirus; CNS, central nervous system; CPAP, continuous positive
airway pressure; CRP, C-reactive protein; CRS, Cytokine Release Syndrome; CSF,
cerebrospinal fluid; CT, computed tomography; CTCAE, Common Terminolog y
Criteria for Adverse Events; DIC, disseminated intravascular coagulation; EEG,
electroencephalogram; EBV, Epstein-Barr virus; G, grade; G-CSF, granulocyte-colony
stimulating factor; GGT, gamma-glutamyl transferase; h, hours; HLH, hemophagocytic
lymphohistiocytosis; ICANS, immune effector cell-associated neurotoxicity syndrome;
ICE, Immune Effector Cell-Associated Encephalopathy; ICU, intensive care unit; IgG,
immunoglobulin G; ISTH, International Society on rombosis and Haemostasis; IV,
intravenous; LDH, lactate dehydrogenase; LLN, lower limit of normal; MRI, magnetic
resonance imaging ; PCR, polymerase chain reaction; PJP, Pneumocystis jirovecii pneumonia
PT, prothrombin time; PTT, partial thromboplastin time
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical
tools and resources, is available at www.asco.org/supportive-care-guidelines.
