Recommendation Grading
Type Benefit/harm Evidence Quality
Strength of
Recommendation
EB Evidence-
based
B Benefits
outweigh harms
H High Strong
FC
Formal
consensus
H Harms outweigh
benefits
I Intermediate Moderate
IC Informal
consensus
B/H Relative balance
of benefits and
harms
L Low Weak
U Benefits/harms
ratio uncertain
Ins Insufficient
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Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncolog y
Guideline. is resource is a practice tool based on ASCO
®
practice guidelines and is not intended
to substitute for the independent professional judgment of the treating physician. Practice guidelines
do not account for individual variation among patients. is pocket guide does not purport to
suggest any particular course of medical treatment. Use of the practice guidelines and this resource
are voluntary. e practice guidelines and additional information are available at www.asco.org/
supportive-care-guidelines. Copyright © 2020 by American Society of Clinical Oncolog y.
All rights reserved.
ASCOCAC05203
Abbreviations
FDA, Food and Drug Administration; NSAIDs, non-steroidal anti-inflammatory drugs;
TNF, tumor necrosis inhibitor
Source
Eric J. Roeland, MD; Kari Bohlke, ScD; Vickie E. Baracos, PhD; Eduardo Bruera, MD;
Egidio del Fabbro, MD; Suzanne Dixon, MPH, MS, RD; Marie Fallon, MD; Jørn Herrstedt,
MD, DMSci; Harold Lau, MD; Mary Platek, PhD, MS, RD; Hope S. Rugo, MD; Hester H.
Schnipper, LICSW; omas J Smith, MD; Winston Tan, MD; Charles L. Loprinzi, MD.
Management of Cancer Cachexia: ASCO Guideline. J Clin Oncol. 2020 May 20
doi: 10.1200/JCO.20.00611
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical tools
and resources, is available at www.asco.org/supportive-care-guidelines.
