27
Table 5. Airway Evaluation, Inclusion, and Exclusion
Criteria for Resectability Before or During Surgical
Intervention
Exclusionary conditions before or at time of ATC surgery
• Patient condition, goals of care or decision-making capacity unsuitable for surgery
• High volume ATC metastases
b
Anticipated prohibitive morbidity from required surgical procedure?
• Unacceptably high risk of extensive laryngeal, tracheal, bilateral nerve, esophageal,
and/or vascular resection required to achieve R0/R1 resection
• Anticipated time of post-operative recovery prohibitive in the context of anticipated
need for additional superimposed therapies (e.g., chemoradiotherapy)
a
R0: negative microscopic and gross margin resection, R: negative gross margin resection.
b
High-volume metastatic disease should preclude surgery, but coexistent metastatic DTC or
oligometastatic/low-volume metastatic ATC should not necessarily preclude surgery.
Table 6. Examples of Concurrent (in Combination with
Radiation Therapy) Chemotherapy Regimens in
Patients with Anaplastic Thyroid Cancer
Regimen Agents/dosages Frequency
Paclitaxel/
Carboplatin
Paclitaxel 50 mg/m
2
, carboplatin area under the curve
(AUC)2 IV
weekly
Docetaxel/
Doxorubicin
Docetaxel 20 mg/m
2
IV, Doxorubicin 20 mg/m
2
IV
weekly
Paclitaxel
Paclitaxel 30–60 mg/m
2
IV
weekly
Docetaxel
Docetaxel 20 mg/m
2
IV
weekly
(cont'd)
