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ESLIP03214
Disclaimer
is pocket guide attempts to define principles of practice that should produce high-quality patient care. It
focuses on the needs of primary care practice but also is applicable to providers at all levels. is pocket guide
should not be considered exclusive of other methods of care reasonably directed at obtaining the same results.
e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer
consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors
endorse any product or service associated with the distributor of this clinical reference tool.
Source
Connie Newman (Chair), Michael J. Blaha, Jeffrey B. Boord, Bertrand Cariou, Alan Chait, Henry
Fein, Henry Ginsberg, Ira Goldberg (Co-Chair), M. Hassan Murad, Savitha Subramanian, and Lisa
R. Tannock. Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical
Practice Guideline. J Clin Endocrinol Metab. 2020;105(12).
Abbreviations
ASCVD, atherosclerotic cardiovascular disease; CAC, coronary artery calcium; CKD, chronic kidney
disease; CV, cardiovascular; CVD, cardiovascular disease; FH, familial hypercholesterolemia; GHD,
growth hormone deficiency; GI, gastrointestinal; EPA, eicosapentaenoic acid; HDL-C, high-density
lipoprotein cholesterol; LDL, low-density lipoprotein; LDL-C, low-density lipoprotein cholesterol;
Lp(a), lipoprotein(a); MetS, metabolic syndrome; PCSK9, Proprotein convertase subtilisin/kexin type
9; T1D, type 1 diabetes; T2D, type 2 diabetes; TG, triglycerides
Grading System
Quality of Evidence
High Quality Moderate Quality Low Quality Very Low Quality
Description of
Evidence
• Well-performed
RCTs
• Very strong
evidence from
unbiased
observational
studies
• RCTs with some
limitations
• Strong evidence
from unbiased
observational
studies
• RCTs with
serious flaws
• Some
evidence from
observational
studies
• Unsystematic
clinical
observations
• Very indirect
evidence from
observational
studies
Strength of Recommendation
Strong (1):
"ES
recommends…"
Benefits clearly
outweigh harms
and burdens or
vice versa
1|⊕⊕⊕⊕
1|⊕⊕⊕
1|⊕⊕
1|⊕
Conditional (2):
"ES suggests…"
Benefits closely
balanced with
harms and
burdens
2|⊕⊕⊕⊕
2|⊕⊕⊕
2|⊕⊕
2|⊕
Ungraded Good Practice Statement UGPS
