OMA Guidelines Bundle

Obesity Pharmacotherapy - OMA Obesity Algorithm 2023

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22 Supplements and Functional Foods Common Functional Foods Mechanism of Action Effects Side Effects Dietary fiber May increase sense of fullness with meals, delay carbohydrate absorption, reduce fatty liver, and increase insulin sensitivity. While increased fiber may increase satiety and marginally decrease percent body fat, reported weight loss is inconsistent. Viscous fiber may promote mild weight loss. Some patients may experience abdominal bloating or flatulence. Prebiotics While they may include non- carbohydrates, prebiotics usually contain indigestible oligosaccharides (e.g., f ructo- oligosaccharides) that may stimulate intestinal growth (colonic lactobacilli and bifidobacteria), which may promote a microbiome conducive to weight loss. Some human studies support weight loss. Weight loss most consistently reported in rodents. Bloating, flatulence Probiotics Bacteria such as lactobacilli (found in yogurt, dairy products, and sauerkraut) may provide protection against unfavorable yeast overgrowth and pathogenic bacteria. Some human studies support weight loss. Weight loss most consistently reported in rodents. Generally safe, small risk of systemic infection in at-risk individuals. Caffeine with or without plant extracts May reduce hunger, increase fat oxidation, and improve alertness. Some studies suggest minor weight loss with caffeine-containing foods and products. High doses can cause anxiety, tremors, cardiac dysrhythmias.

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