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2020 ISTH TTP Pocket Guideline with GPS

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2 Interpretation of the Certainty in Evidence of Effects using the GRADE framework H = High We are very confident that the true effect lies close to that of the estimate of the effect. M = Moderate We are moderately confident in the effect estimate. e true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. L = Low Our confidence in the effect estimate is limited. e true effect may be substantially different from the estimate of the effect. VL = Very Low We have very little confidence in the effect estimate. e true effect is likely to be substantially different from the estimate of effect Interpretation of Strong and Conditional Recommendations using the GRADE framework Implications S = Strong recommendation C = Conditional recommendation For patients Most individuals in this situation would want the recommended course of action and only a small proportion would not. e majority of individuals in this situation would want the suggested course of action, but many would not. For clinicians Most individuals should receive the intervention. Formal decision aids are not likely to be needed to help individuals make decisions consistent with their values and preferences. Different choices will be appropriate for individual patients consistent with his or her values and preferences. Use shared- decision making. Decision aids may be useful in helping patients make decisions consistent with their individual risks, values and preferences. For policy makers e recommendation can be adapted as policy or performance measure in most situations Policy-making will require substantial debate and involvement of various stakeholders. Performance measures should assess whether decision making is appropriate. * Strong recommendations are indicated by statements that lead with "recommend", while conditional recommendations are indicated by statements that lead with "suggest"

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