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2020 ISTH TTP Pocket Guideline with GPS

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Disclaimer is pocket guide attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. is pocket guide should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. Abbreviations cTTP, hereditary or congenital TTP; FVIII, factor VIII; INR, international normalized ratio; iTTP, immune-mediated TTP; MCV, mean corposcular value; SCT, stem cell transplantation; TMA, thrombotic microangiopathy; TPE, therapeutic plasma exchange; TTP, thrombotic thrombocytopenic purpura e guidelines provide evidence-based recommendations that have been developed using GR ADE (Grading of Recommendations Assessment, Development, and Evaluation) methodolog y. GR ADE involves structured literature review, systematic reviews and meta- analyses of combined data, and expert discussion to assess the certainty in the evidence and determine the strength of each recommendation. Source X. Long Zheng, Sara K. Vesely, Spero R. Cataland, et al. ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. Journal of rombosis and Haemostasis. 2020 July doi:10.1111/jth.15006. X. Long Zheng, Sara K. Vesely, Spero R. Cataland, et al. ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. Journal of rombosis and Haemostasis. 2020 July doi:10.1111/jth.15010. X. Long Zheng, Sara K. Vesely, Spero R. Cataland, et al. (2020). Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura. Journal of rombosis and Haemostasis, 18(10), 2503-2512. doi: 10.1111/jth.15009 106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © 2020 All rights reserved ISTHTTP09203a_GPS

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