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Tardive Dyskinesia

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Disclaimer This pocket guide attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. This pocket guide should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician after consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. The most common U.S. trade names are included for reference only. At the time of publication, some of these products may be manufactured only as generic products. Other medications or other formulations of the listed medications may be available in Canada. Abbreviations AIMS, Abnormal Involuntary Movement Scale; AUC, area under the curve; C max , maximum plasma concentration; CrCl, creatinine clearance; CYP, cytochrome P450; DISCUS, Dyskinesia Identification System-Condensed User Scale; HTBZ, dihydrotetrabenazine; VMAT2, vesicular monoamine transporter 2 Source American Psychiatric Association: Practice Guideline for the Treatment of Patients With Schizophrenia, 3rd Edition. Washington, DC, American Psychiatric Publishing, 2021 106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies at GuidelineCentral.com Copyright © American Psychiatric Association. All rights reserved. APASCH11203cTD Grading Recommendations Grade Description 1 Recommendation: indicates confidence that the benefits of the intervention clearly outweigh harms. 2 Suggestion: indicates greater uncertainty: although the benefits of the statement are still viewed as outweighing the harms, balance of benefits and harms is more difficult to judge, or the benefits or the harms may be less clear. With a suggestion, patient values and preferences may be more variable, and this can influence the clinical decision that is ultimately made. Grade Strength of Evidence A High: high confidence that the evidence reflects the true effect. Further research is very unlikely to change our confidence in the estimate of effect. B Moderate: moderate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of effect and may change the estimate. C Low: low confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of effect and is likely to change the estimate.

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