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Tardive Dyskinesia

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  ➤ This pocket guide includes selected statements from the American Psychiatric Association Practice Guideline for the Treatment of Patients with Schizophrenia, 3rd edition related to the assessment and treatment of tardive dyskinesia.   ➤ Individuals with tardive dyskinesia, as with any individual with schizophrenia, should be treated in the context of a person-centered treatment plan that includes evidence-based non-pharmacological and pharmacological treatments.   ➤ Tardive syndromes can occur after exposure to any antipsychotic medication. In adult patients treated with first-generation antipsychotic agents, tardive dyskinesia occurs at a rate of approximately 4%-8% per year, which is about three times the annual risk with second generation antipsychotic agents.   ➤ Various factors are associated with greater vulnerability to tardive dyskinesia. Patients at increased risk for developing abnormal involuntary movements include individuals older than 55 years; women; individuals with a mood disorder, substance use disorder, intellectual disability, or central nervous system injury; individuals with high cumulative exposure to antipsychotic medications, particularly high potency dopamine D2 receptor antagonists; and patients who experience acute dystonic reactions, clinically significant parkinsonism, or akathisia. Abnormal involuntary movements can also emerge or worsen with antipsychotic cessation.   ➤ Please visit the full text guideline at for detailed recommendations on the treatment of schizophrenia as well as detailed information on pharmacology, side effects, and dosing information of antipsychotic medications and VMAT2 inhibitors. Introduction

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