Management
Recommendations on the Management of EoE
Statement
Strength of
recommendation
Quality of
evidence
1. In patients with symptomatic esophageal eosinophilia,
the AGA/JTF suggests using proton pump inhibition
over no treatment.
Conditional Very low
2. In patients with EoE, the AGA/JTF recommends pical
glucocorticosteroids over no treatment.
Strong Moderate
3. In patients with EoE, the AGA/JTF suggests
topical glucocorticosteroids rather than oral
glucocorticosteroids.
Conditional Moderate
4. In patients with EoE, the AGA/JTF suggests using
elemental diet over no treatment.
Comment: Patients who put a higher value on avoiding
the challenges of adherence to an elemental diet and
the prolonged process of dietary reintroduction may
reasonably decline this treatment option.
Conditional Moderate
5. In patients with EoE, the AGA/JTF suggests using an
empiric, 6-food elimination diet over no treatment.
Comment: Patients who put a higher value on
avoiding the challenges of adherence to diet involving
elimination of multiple common food staples and
the prolonged process of dietary reintroduction may
reasonably decline this treatment option.
Conditional Low
6. In patients with EoE, the AGA/JTF suggests using an
allerg y testing-based elimination diet over no treatment.
Comment: Due to the potential limited accuracy
of currently available, allerg y-based testing for the
identification of specific food triggers for EoE, patients
may prefer alternative medical or dietary therapies to an
exclusively testing-based elimination diet.
Conditional Very low
7. In patient with EoE in remission after short-term use
of topical glucocorticosteroids, the AGA/JTF suggests
continuation of topical glucocorticosteroids over
discontinuation of treatment.
Comments: Patients who put a high value on the
avoidance of long-term topical steroid use and its
possible associated adverse effects, and/or place a
lower value on the prevention of potential long-term
undesirable outcomes (ie, recurrent dysphagia, food
impaction, and esophageal stricture), could reasonably
prefer cessation of treatment after initial remission is
achieved, provided clinical follow-up is maintained.
Conditional Very low
