Key Points
➤ Eosinophilic esophagitis (EoE) was first characterized in the early 1990s
and understood to be a food antigen-driven Th2 inflammatory condition.
➤ A large body of evidence suggests that EoE subjects have aeroallergen
sensitization and concurrent atopic diseases including asthma, allergic
rhinitis and eczema.
• There is a close interaction between these organ-specific diseases and a potential for
common triggering antigens in EoE and other atopic conditions.
GRADE Strength of Recommendations and Implications
Grade Quality of Evidence
High We are very confident that the true effect lies close to that of the
estimate of the effect.
Moderate We are moderately confident in the effect estimate. e true effect is
likely to be close to the estimate of the effect, but there is a possibility
that it is substantially different.
Low Our confidence in the effect estimate is limited. e true effect may be
substantially different from the estimate of the effect.
Very low We have very little confidence in the effect estimate. e true effect is
likely to be substantially different from the estimate of effect.
Knowledge Gap May vary depending upon the severity of initial clinical presentation.
Grade Strength of Recommendation
For the Patient For the Clinician
Strong Most individuals
in this situation
would want the
recommended course
of action, and only
a small proportion
would not.
Most individuals should receive the
recommended course of action. Formal
decision aids are not likely to help individuals
make decisions consistent with their values
and preferences.
Conditional e majority of
individuals in this
situation would want
the suggested course
of action, but many
would not.
Different choices will be appropriate for
different patients. Decision aids may be useful
in helping individuals in making decisions
consistent with their values and preferences.
Clinicians should expect to spend more
time with patients when working towards a
decision.
No
recommendation
The confidence in the effect estimate is so
low that any recommendation is speculative
at this time.