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Functional Hypothalamic Amenorrhea

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Diagnosis Table 1. Potential Etiologies of Amenorrhea Congenital malformation Septo-optic dysplasia Holoprosencephaly Encephalocele Constitutional delay Genetic conditions Congenital deficiency of hypothalamic or pituitary transcription factors (gonadotropin deficiency) Single-gene mutations (hypogonadotropic hypogonadism) Hyperprolactinemia Pituitary gland or stalk damage Tumors and cysts [hypothalamic or pituitary tumor (hormone-secreting ), craniopharyngioma, Rathke cleft cyst, other cysts, and tumors] Infiltrative disorders (germinoma, autoimmune hypophysitis, sarcoidosis, hemochromatosis, tuberculosis, Langerhans cell histiocytosis, IgG4-related hypophysitis) Irradiation Infarction [apoplexy in pre-existing pituitary tumors, or following postpartum hemorrhage (Sheehan syndrome)] Surgery Trauma Others Eating disorders Competitive athletics Chronic disease Mood disorders Stress or psychiatric illness Drugs Thyroid Hypothyroidism or hyperthyroidism Diagnosis

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