Endocrine Society GUIDELINES Bundle (free trial)

Paget's Disease of Bone

Endocrine Society GUIDELINES Apps brought to you free of charge courtesy of Guideline Central. All of these titles are available for purchase on our website, GuidelineCentral.com. Enjoy!

Issue link: http://eguideline.guidelinecentral.com/i/1140175

Contents of this Issue

Navigation

Page 2 of 5

Diagnosis Table 1. Symptoms and Complications of Paget's Disease of Bone System Complication Musculoskeletal • Bone pain • Bone deformity • Osteoarthritis of adjacent joints • Acetabular protrusion • Fractures • Spinal stenosis Neurological • Hearing loss • Tinnitus • Cranial nerve deficits (rare) • Basilar impression • Increased cerebrospinal fluid pressure • Spinal stenosis • Paraplegia, quadriplegia, vascular steal syndrome Cardiovascular • Congestive heart failure • Increased cardiac output • Aortic stenosis • Generalized atherosclerosis • Endocardial calcification Metabolic • Immobilization ▶ Hypercalciuria ▶ Hypercalcemia • Hyperuricemia • Nephrolithiasis Neoplasia • Sarcoma (osteosarcoma, chondrosarcoma, and fibrosarcoma) • Giant cell tumor Table 2. Recommended Bisphosphonate Dosing Regimens Drug Dosage a Alendronate • 40 mg/d PO for 6 mo. • Retreatment may be required between 2 and 6 y. Risedronate • 30 mg/d PO for 2 mo. • Retreatment may be required between 1 and 5 y. Zoledronate b • 5 mg given as a single IV infusion over 15 min. • Retreatment is seldom required within 5 y. a Vitamin D deficiency should be corrected before administration of these drugs. b e authors recognize that the official generic name for this drug is "zoledronic acid." However, that is a misnomer. In fact, it is the sodium salt, not the acid, that is used in medical practice. erefore, we have elected to use "zoledronate," which is consistent with the nomenclature for bisphosphonates. Brand names: alendronate (Fosamax ® ), risedronate (Actonel ® ), zoledronate (Reclast ® ). Treatment

Articles in this issue

Archives of this issue

view archives of Endocrine Society GUIDELINES Bundle (free trial) - Paget's Disease of Bone